#Genomic Sequencing

[ricisidro]

BA.2.X New #Omicron lineage | via @Tuliodna, @EricTopol

https://x.com/tuliodna/status/1752996491948327126?s=46&t=i2uHiaqre0-vH8-HVYuWsw

As #SARSCoV2 continue to evolve, a new lineage has been detected in South Africa (SA) with >100 mutations (>30 on spike) and multiple deletions.

No sign of widespread, on the opposite, BA.2.86/JN.1 continue to dominate and SA is following the epidemic in many fronts with no sign of increasing cases, hospitalisation and deaths.

#biosurveillance #genomicsurveillance

[iamthekaijuking]

This just in, starfish are a radially symmetrical head with a stomach.

God I love echinoderms

If you told someone that there’s an entire group of animals that develop butt first as embryos are born bilateral but then grow a radially symmetrical head like a cancer in their side that then bursts out and lives as a completely separate organism from its birth form and moves via hydraulic systems…

They wouldn’t believe you. Yet one of the most beloved cartoon characters is one of them.

[yonker-tonker]

Arcee is like a creature to me

[mindblowingscience]

Antibiotics are a lifesaving tool. Yet, due to their chronic overuse, microbes are evolving and developing immunity against them. As a result, once-effective medications can no longer stave off infections, complicating treatment and increasing mortality. A University at Albany study recently published in the journal Nature Communications identified a new genetic mechanism that allows antimicrobial resistance to spread among lethal bacteria.

Continue Reading.

[invinciblevalentine]

hojo pisses me tf off. Like yeah yeah human rights violations unethical science blah blah blah HAVE WE CONSIDERED THE DAMAGE HE’S BEEN DOING TO THE FF7 SCIENTIFIC COMMUNITY????

Listen he’d be a morally grey character if his work led to reproducible results that could benefit the rest of humanity but GOOD GAIA does he not even do that.

his sample sizes are SHIT. his experimental design is SHIT. his documentation is SHIT. his biases are VISIBLE. I’m astral projecting into the ff7 universe just to strangle this man and take away whatever diploma he got bc clearly he hired someone to do his PhD for him.

AND HE INSPIRED SO MANY TO FOLLOW IN HIS SHITTY SHITTY FOOTSTEPS. like the only two things we could even marginally call reproducible is his work in making the SOLDIER program and Fuhitos attempt to replicate it with his RAVENs. and even then there were no improvements on the procedure or attempts to create a procedure that left the patients in better health.

which is a CRIMINALLY STUPID THING TO DO TO YOUR GIANT SUPER SOLDIER ARMY. WYM THAT INSANITY IS JUST A POSSIBLE SIDE EFFECT?????

an argument could be made that we just don’t SEE hojos documentation and shit bc we’re playing through the eyes of people who don’t know all that shit.

HOWEVER. if hojo was actually doing any of that he’d have spotted the degradation problem in his animal models first.

BECAUSE WHO THE FUCK JUMPS YO HUMAN SUBJECTS??? ITS NOT JUST UNETHICAL ITS EXTREMWLY EXPENSIVE TO MAINTAIN THE WELLBEING OF AND ACQUIRE A WHOLE HUMAN PERSON.

if he’d started with, like, mouse models to demonstrate how mako treatments affect mammals, he’d have gotten so much more work done and achieved more reliable results. WITH A FRACTION OF THE COST.

BUT NOOOOOOOOOO. APPARENTLY SHINRA SHITS MONEY SO WHO CARES ABOUT SAMPLE SIZES AND STATISTICAL TESTS AND REPRODUCIBLE RESULTS!!

HOJO IS A HACK AND A FRAUD AND A SHIT SCIENTIST TO BOOT. WATCH YOUR BACK BITCH YOUVE HOED YOUR LAST JO.

[beemovieerotica]

may i suggest davidusjoneium manumos for your bacteria name poll

a;sldkjfal;sdk okay so POTENTIALLY i could name it something really weird but i will absolutely need to have a justification to my boss for why it is named that thing. also this is fairly far off in the future / not 100% certain because i still have to do all the shit required of describing a new species

[etoilesombre]

’til the whole thing comes apart (Chapter 3) by x_etoile_x [AO3]

Chapters: 4/6

Fandom: The X-Files

Rating: Explicit

Warnings: Creator Chose Not To Use Archive Warnings

Relationships: Alex Krycek/Fox Mulder

Characters: Alex Krycek, Fox Mulder, Dana Scully

Additional Tags: Angst, Oral Sex, Anal Sex, Rough Sex, POV Fox Mulder, Canon Disabled Character, Oops this grew a plot, Some Weirdness About Blood, Lots of Mulder Working Through His Nonsense, The Boys Try to Save the World, CSM is Presumed Dead, Surely everything will be fine, AU After The Red and the Black, Holiday Series, Valentine's Day is coming (they both want to avoid it), Alex is really trying, Discussion of M/F Sex, in the context of a fantasy during phone sex, which there also is, it's all gonna go to hell eventualy, but they're having a honeymoon phase first, Mulder tries bottoming, background case file

Series: Part 3 of like the western front

Summary:

CHAPTER THE THIRD: In which Mulder slow walks solving a case and the guys try desperately to avoid the outside world, but the world does not entirely cooperate (excerpt under the cut)

Along with a bonus interlude chapter, in which Mulder decides he'd like to try being the one who gets fucked for once, and is annoyingly Mulder-ish about it, but in the end everybody has a good time.

“Hi." Mulder looks around, a little stunned. "Where the hell are we?” “No place.” Alex shrugs, like this isn’t the type of house your average celebrity would consider a status symbol. “I'm tired of hotels. Friend of a girlfriend of a guy I worked with once is a travel agent, told her I wanted something nice. It’s off season, easy.” “Yeah, easy if you live in a world where money’s pretend." Mulder's tone is cutting. He can justify taking funding for research, but a mountain retreat provided by the conspiracy feels a little too close to being bought off. “Come on Alex, did you think this was going to impress me?” For the space of a heartbeat Alex looks crestfallen, then his expression flattens. “Really? Is this what you’re picking to be an asshole about tonight?” Mulder immediately regrets starting out that way. He has gone into every interaction for years wanting to hurt Alex by default, and it turns out to be a hard habit to break. “I didn’t mean—” “Yeah you did,” Alex interrupts, bitter. Spots of color appear high on his cheeks; Mulder must have hit a nerve. “You know, I didn’t ask to be a part of any of this. In case you haven’t noticed, my life is pretty fucked up. And it’s mostly because of the bastards I work for, on both sides." His eyes flash with defiance. "So no, I don't feel bad about living well off their money when I have the chance. Which is rarely. And no, I don't particularly care what you think about it.” That’s so patently untrue it hurts. Besides, Alex looks really good when he’s a little bit pissed off; Mulder decides there’s no reason to pick this as the place to stand on strictest principle. “I guess this is what you meant when you said I’d be annoying about things,” he offers, by way of apology. “You wouldn’t be you otherwise,” Alex responds, with a resigned half smile. “It’s fine if you don’t want to stay. I mean, I think you’re being stupid, but I get it.” That easy acquiescence pulls on Mulder’s heart. “No. Sorry.” He reaches out and cups Alex’s face, and Alex shifts almost imperceptibly into the touch, like a plant turning toward light. “Sorry,” he whispers again, guiding their lips together.

[eeleye-mcshitposts]

ONE of these fucks does NOT belong.

[everythingaboutbiotech]

Common uses of bioinformatics

💡Sequence analysis Analyzing DNA and protein sequences to identify genes, regulatory regions & mutations.

💡Gene expression Analyzing RNA expression data from experiments like microarrays or RNA-seq to understand gene regulation.

💡Phylogenetics Constructing evolutionary relationships between organisms based on genetic data and genomic comparisons.

💡Molecular modeling Predicting protein structure and docking drugs to proteins using computational modeling and simulation.

💡Databases & Data mining Developing databases like GenBank to store biological data and mining it to find patterns.

💡Genomics Studying entire genomes, including sequencing and assembling genomes as well as identifying genes and genomic variations.

Follow @everythingaboutbiotech for useful posts.

[aunteutis]

god, ben stiller's music taste in this is so good

[smol-blue-bird]

I love old books about the future. Currently reading The Physics of the Future by Michio Kaku, and he keeps saying that humans will one day be able to fit their genomes on a CD-ROM

[dollelujah]

These pride advertisements are getting out of hand

[shallowseeker]

Is yours the kind of chronic illness you'll recover from? You definitely don't have to answer or give personal details, but I really hope you feel better!

No, it's okay. It's likely that I won't fully recover, but in the past decade, there have been WAY more treatments available that turn down the immune system and combat scarring. And yes, I'm much better, thanks!💖 In a nutshell,

my immune system malfunctioned after an infection, and now it attacks my body in big, big ways—with a tendency to damage the muscles and lungs!

My situation got even weirder because it started attacking my nerves and heart from 2020 onward, which ... usually ppl with my diagnosis, get respiratory failure, not overt heart issues. (Long story, but I got undiagnosed, then rebiopsied, then rediagnosed the same thing *with extra notes.) Anyhoo, the new developments impacted my mobility and stamina in even crazier ways than I was used to. (I have until recently worked a full-time job and pretty much spent ~5-6 days in a gym with an expensive physical therapist just to keep my body functional. Before, I had an acquired skeletal myopathy, but I was able to run a 5k in 42 minutes... I trained like an Olympian and while had to rest a lot more than most, I could do it!)

Now... I can't even manage one day a week of light activity. It's a big adjustment, even for me! I'm having to noodle on how to best manage it going forward. It's always this confusing situation of "Is this the primary illness, secondary damage, or the side effects of toxic medications?"

I'm doing a pretty good job if I do say so myself.

[sleepysera]

"With the announcement that the Human Genome Project had mapped all of the genetic material in the human chromosomes, a new era in the understanding of genetics began. The discovery of new genes is announced every day, and it is only a matter of time before the genetic mechanisms of mood disorders is only one of the goals of work in this field. Just as important will be understanding the epigenetic mechanisms by which genes turn on and off and other mechanisms that regulate the expression and work of the instructions encoded in the DNA molecule.

The first genetic approach to pay off in changing treatment is likely to be pharmacogenomics, the field within genetics that investigates genetic factors associated with responses to particular pharmaceuticals rather than with risk of disease. The promise of pharmacogenomics is that therapeutic agents can be rationally selected, based on a person's genetic profile rather than the trial-and-error process patients must now endure. In the not-too-distant future, a blood test will show whether lithium or valproate or lamotrigine or some as yet undiscovered drug will be the best treatment for a particular individual with bipolar disorder. A blood test may be able to identify the bipolar patients who can safely take an antidepressant."

-Francis Mark Mondimore, Bipolar Disorder (2014)

[eisenvulcanstein]

To help save kākāpōs, we must understand their genes | Popular Science

[yasbxxgie]

Genomic analyses of individuals living with HIV-1 revealed a region in chromosome 1 that is associated with reduced viral loads specifically in populations with African ancestry. This could point to much-needed therapeutic targets to address the global public-health crisis caused by HIV-1.

[h/t]